{"id":661,"date":"2019-11-30T12:51:29","date_gmt":"2019-11-30T03:51:29","guid":{"rendered":"http:\/\/prologue266.cafe24.com\/?p=661"},"modified":"2019-11-30T12:51:29","modified_gmt":"2019-11-30T03:51:29","slug":"210f6d655340039efb9f31c7d68f274266f847bf0e22042f3f6b9074eccec7dbec210f6d655340039efb9f31c7d68f274266f847bf0e22042f3f6b9074eccec7db9a210f6d655340039efb9f31c7d68f274266f847bf0e22042f3f6b9074eccec7d-4","status":"publish","type":"post","link":"https:\/\/dreampilafitnews.co.kr\/?p=661","title":{"rendered":"\uc6b0\ub9ac \ubab8\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac \uc870\uc808 \uc2a4\uc704\uce58\ub97c \ucc3e\ub2e4"},"content":{"rendered":"<p>\uc6b0\ub9ac \ubab8\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac \uc870\uc808 \uc2a4\uc704\uce58\ub97c \ucc3e\ub2e4 &#8211; (\uc7ac)\uc758\uc57d\ubc14\uc774\uc624\ucee8\ubc84\uc83c\uc2a4\uc5f0\uad6c\ub2e8 \uae40\uc131\ud6c8 \ub2e8\uc7a5, \uc0ac\uc774\uc5b8\uc2a4(Science) \uac8c\uc7ac &#8211; \u00a0 \u25a1 (\uc7ac)\uc758\uc57d\ubc14\uc774\uc624\ucee8\ubc84\uc83c\uc2a4\uc5f0\uad6c\ub2e8 \uae40\uc131\ud6c8 \ub2e8\uc7a5\uacfc \uc5f0\uc138\ub300\ud559\uad50 \ud55c\uc815\ubbfc \uad50\uc218 \ub4f1\uc774 \uacf5\ub3d9\uc5f0\uad6c\ub97c \ud1b5\ud574 LARS1(leucyl-tRNA synthetase 1) \ud6a8\uc18c\uac00 \uc544\ubbf8\ub178\uc0b0\uacfc \ud0c4\uc218\ud654\ubb3c\uc758 \uc138\ud3ec\ub0b4 \uc218\uc900\uc744 \uc778\uc2dd\ud574 \ub2e8\ubc31\uc9c8 \ud569\uc131\uacfc \uc5d0\ub108\uc9c0 \uc0dd\uc0b0\uc758 \uade0\ud615\uc744 \uc774\ub8e8\ub294 \ud1b5\ud569\ud615 \ub300\uc0ac\uc870\uc808 \uc2a4\uc704\uce58\uc758 \uc5ed\ud560\uc744 \ud558\uace0 \uc788\uc74c\uc744 \uc138\uacc4 \ucd5c\ucd08\ub85c \uaddc\uba85\ud558\uc600\ub2e4\uace0 \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80(\uc7a5\uad00 \ucd5c\uae30\uc601)\ub294 \ubc1d\ud614\ub2e4. \u00a0 \u25cb \ubcf8 \uc5f0\uad6c\ub294 \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80\uac00 \uc138\uacc4\uc801 \uc6d0\ucc9c\uae30\uc220 \ud655\ubcf4\ub97c \uc704\ud574 \ucd94\uc9c4\ud558\ub294 \uae00\ub85c\ubc8c\ud504\ub860\ud2f0\uc5b4\uc0ac\uc5c5\uc758 \uc9c0\uc6d0\uc73c\ub85c \uc774\ub8e8\uc5b4\uc84c\uc73c\uba70, \uacfc\ud559\uae30\uc220\ubd84\uc57c\uc758 \uad8c\uc704 \uc788\ub294 \ud559\uc220\uc9c0\uc778 <strong>Science \uc9c0<\/strong><strong> (IF 41.063)\uc5d0<\/strong><strong> 2019\ub144 11\uc6d4<\/strong> <strong>29\uc77c<\/strong>\uc5d0 \uc628\ub77c\uc778 \uac8c\uc7ac\ub418\uc5c8\ub2e4. * \ub17c\ubb38\uba85: <em>Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1<\/em> \u00a0 \u25a1 \uc544\ubbf8\ub178\uc0b0\uc740 \ub2e8\ubc31\uc9c8\uc744 \uad6c\uc131\ud558\ub294 \uae30\ubcf8 \uc601\uc591\uc18c\ub85c\uc11c \uc6b0\ub9ac \ubab8\uc744 \uad6c\uc131\ud558\ub294 \uac00\uc7a5 \uc911\uc694\ud55c \uad6c\uc131\uc131\ubd84\uc774\uc9c0\ub9cc \ubab8\uc758 \uc5d0\ub108\uc9c0 \uc218\uc900\uc774 \ub0ae\uc544\uc9c0\uba74 \uc5d0\ub108\uc9c0\ub97c \ubc1c\uc0dd\uc2dc\ud0a4\ub294 \uc5f0\ub8cc\ub85c\ub3c4 \uc0ac\uc6a9\ub41c\ub2e4. \ud558\uc9c0\ub9cc \uc544\ubbf8\ub178\uc0b0\uc774 \ubab8\uc758 \uc5d0\ub108\uc9c0 \uc218\uc900\uc744 \uc5b4\ub5bb\uac8c \uac10\uc9c0\ud558\uc5ec \uc774\ub7ec\ud55c \uc804\ud658\uc774 \uc77c\uc5b4\ub098\ub294 \uc9c0\uc5d0 \ub300\ud574\uc11c\ub294 \uc544\uc9c1 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\ub2e4. \u00a0 \u25cb \uc5f0\uad6c\ub2e8\uc740 \uc9c0\ub09c 2012\ub144 LARS1\uc774 \uc138\ud3ec\ub0b4 \uc544\ubbf8\ub178\uc0b0\uc911 \ud558\ub098\uc778 \ub958\uc2e0 (leucine)\uc744 \uac10\uc9c0\ud558\uc5ec \ub2e8\ubc31\uc9c8\ud569\uc131\uacfc\uc815\uc744 \ud65c\uc131\ud654\ud558\ub294 \uc2a4\uc704\uce58\ub85c\uc11c \uc791\ub3d9\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc138\uacc4 \ucd5c\ucd08\ub85c \ubc1c\uacac\ud558\uc5ecCell\uc9c0\uc5d0 \ubc1c\ud45c\ud55c \ubc14 \uc788\ub2e4. * \ub17c\ubb38\uba85: <em>Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway<\/em> \u00a0 \u25cb \uc9c0\ub09c \uc5f0\uad6c\uc5d0\uc11c\ub294LARS1\uc758 \uc2a4\uc704\uce58\uac00 \ub958\uc2e0\uc5d0 \uc758\ud574\u201cOn\u201d\ub41c\ub2e4\ub294 \uac83\uc740\ubc1d\ud614\uc73c\ub098 \uc5b4\ub5bb\uac8c\u201cOff\u201d\ub418\ub294\uc9c0\ub294 \ubc1d\ud600\ub0b4\uc9c0 \ubabb\ud558\uc600\uc5c8\ub2e4.\ubcf8 \uc5f0\uad6c\ub294 \uadf8 \uc9c8\ubb38\uc744 \ud574\uacb0\ud558\uae30 \uc704\ud55c \ud6c4\uc18d \uc5f0\uad6c\uc758 \uacb0\uacfc\ub85c\uc11cLARS1\uc758 \uc544\ubbf8\ub178\uc0b0 \uc2a4\uc704\uce58 \uae30\ub2a5\uc774 \uc6b0\ub9ac \ubab8\uc758 \uc5d0\ub108\uc9c0 \uc0c1\ud0dc\uc5d0 \ub530\ub77c\u201cOn-Off\u201d\ub420 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ucd94\uac00\ub85c \uaddc\uba85\ud558\uc600\ub2e4.\uc989LARS1\uac00 \uc138\ud3ec\uc758 \uc5d0\ub108\uc9c0\uc6d0\uc778ATP\uc758 \uc218\uc900\uc744 \uac10\uc9c0\ud558\uc5ec \uc544\ubbf8\ub178\uc0b0\uc778 \ub958\uc2e0\uc758 \ub300\uc0ac\uc758 \ubc29\ud5a5\uc744 \uc870\uc808\ud558\ub294 \ud1b5\ud569\uc801\uc778 \uae30\ub2a5\uc744 \ud560 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc744 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\uc9c8\ud658 \ubfd0 \ub9cc \uc544\ub2c8\ub77c \uc554,\uc2e0\uacbd,\uadfc\uc721 \uad00\ub828\uc9c8\ud658\uc758 \uce58\ub8cc\uc81c \uac1c\ubc1c \ud0c0\uae43\uc73c\ub85c \uc720\uc6a9\ud558\uac8c \ud65c\uc6a9 \ub420 \uac83\uc774\ub2e4.\u201d\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>&#8220;\uc774 \uc790\ub8cc\ub294 \uacfc\ud559\uae30\uc220\uc815\ubcf4\ud1b5\uc2e0\ubd80\uc758 \ubcf4\ub3c4\uc790\ub8cc\ub97c \uc804\uc7ac\ud558\uc5ec \uc81c\uacf5\ud568\uc744 \uc54c\ub824\ub4dc\ub9bd\ub2c8\ub2e4.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uc6b0\ub9ac \ubab8\uc758 \uc5d0\ub108\uc9c0 \ub300\uc0ac \uc870\uc808 \uc2a4\uc704\uce58\ub97c \ucc3e\ub2e4 &#8211; (\uc7ac)\uc758\uc57d\ubc14\uc774\uc624\ucee8\ubc84\uc83c\uc2a4\uc5f0\uad6c\ub2e8 \uae40\uc131\ud6c8 \ub2e8\uc7a5, \uc0ac\uc774\uc5b8\uc2a4(Science) \uac8c\uc7ac &#8211; \u00a0 \u25a1 (\uc7ac)\uc758\uc57d\ubc14\uc774\uc624\ucee8\ubc84\uc83c\uc2a4\uc5f0\uad6c\ub2e8 \uae40\uc131\ud6c8 \ub2e8\uc7a5\uacfc \uc5f0\uc138\ub300\ud559\uad50 \ud55c\uc815\ubbfc \uad50\uc218 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